4-Hydroxy-2-nonenal: a critical target in oxidative stress?
نویسندگان
چکیده
منابع مشابه
1 4 - hydroxy - 2 - nonenal : a critical target in oxidative stress ? 1
20 In this perspective, we summarize and discuss critical advancements in the study of 421 hydroxy-2-nonenal (4-HNE) as it relates to diseases and clinical complications either caused or 22 exacerbated by oxidative stress. Since its identification in 1980, 4-HNE has been extensively 23 studied with an emphasis on its formation, its role in pathology, and its targets. As a reactive 24 aldehyde, ...
متن کامل4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules.
Oxidative stress is associated with important pathophysiological events in a variety of diseases. It has been postulated that free radicals and lipid peroxidation products generated during the process may be responsible for these effects because of their ability to damage cellular components such as membranes, proteins, and DNA. In the present study, we provide evidence that oxidative stress ca...
متن کاملIkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal.
In unstimulated cells, transcription factor NF-kappaB is retained in the cytoplasm by interaction with the inhibitory protein, IkappaBalpha. Appropriate cellular stimuli inactivate IkappaBalpha by phosphorylation, ubiquination, and proteolytic degradation, which allows NF-kappaB to translocate to the nucleus and modulate gene expression. 4-Hydroxy-2-nonenal (HNE), a major lipid peroxidation pro...
متن کاملPhosphatidylinositol 3 kinase pathway and 4-hydroxy-2-nonenal-induced oxidative injury in the RPE.
PURPOSE 4-Hydroxy-2-nonenal (4-HNE) is a major lipid peroxidation product in the retina and the retinal pigment epithelium. The purpose of the present study was to investigate how NF-E2-related factor-2 (Nrf2) and phosphatidylinositol 3 (PI3K) pathways affect the responses of cultured human retinal pigment epithelial (RPE) cells to 4-HNE. METHODS Cultured ARPE-19 cells were treated with diffe...
متن کاملEffect of 4-Hydroxy-2-Nonenal Modification on -Synuclein Aggregation
Several observations have implicated oxidative stress and aggregation of the presynaptic protein-synuclein in the pathogenesis of PD.-Synuclein has been shown to have affinity for unsaturated fatty acids and membranes enriched in PUFAs, which are especially sensitive to oxidation under conditions of oxidative stress. One of the most important products of lipid oxidation is 4-hydroxynonenal (H...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2016
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00101.2016